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KMID : 0369820090390020085
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 2 p.85 ~ p.91
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Preparation and evaluation of microcrystallized cellulose xanthate-metal-oxytetracycline complexes as antibacterial agents with prolonged antibacterial activity
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Kong Hyo-Sik
Lee You-Na
Lee Yong-Hyun
Kim Young-Mi
Jung Yun-Jin
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Abstract
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Microcrystallized cellulose xanthate-metal-oxytetracycline complexes (MCX-metal-OTC) were prepared and evaluated as a controlled release system for the antibiotics. Microcrystallized cellulose (MC) was chemically modified to xanthated microcrystallized cellulose (MCX). One-bath method, where MCX was reacted with OTC-metal complexes, afforded greater amount of OTC bound to the polymeric matrix than did two-bath method, where MCX-metal complexes were treated with OTC. The OTC release from MCX-metal-OTC was greatly sustained compared with that from a mixture of MC/metal/OTC. Furthermore, MCX-metal-OTC manifested antibacterial activity, which lasted for 11-18 days. These results suggest that MCX-metal-OTC is a polymeric antibiotics with prolonged antibacterial activity.
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KEYWORD
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Controlled release, Coordinate bond, Polymeric drug, Cellulose, Prolonged antibacterial activity and Oxytetracycline
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